Peroxisome size provides insights into the function of autophagy-related proteins.

@article{Nazarko2009PeroxisomeSP,
  title={Peroxisome size provides insights into the function of autophagy-related proteins.},
  author={Taras Y. Nazarko and Jean-Claude Farr{\'e} and Suresh Subramani},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 17},
  pages={
          3828-39
        }
}
Autophagy is a major pathway of intracellular degradation mediated by formation of autophagosomes. Recently, autophagy was implicated in the degradation of intracellular bacteria, whose size often exceeds the capacity of normal autophagosomes. However, the adaptations of the autophagic machinery for sequestration of large cargos were unknown. Here we developed a yeast model system to study the effect of cargo size on the requirement of autophagy-related (Atg) proteins. We controlled the size of… CONTINUE READING

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