Peroxisome proliferator-activated receptors mediate pleiotropic actions of statins.

High plasma concentrations of LDL-cholesterol (LDL-c) are a major risk factor for atherosclerosis, a chronic inflammatory disease of the large arteries. Statins are potent inhibitors of cholesterol biosynthesis which efficiently decrease plasma LDL-c concentrations. A large number of clinical trials has shown beneficial effects of statins in the primary and… CONTINUE READING