Peroxisome proliferator-activated receptors and the control of inflammation.

  title={Peroxisome proliferator-activated receptors and the control of inflammation.},
  author={A. Cabrero and Joan Carles Laguna and Manuel Garc{\'i}a Vazquez},
  journal={Current drug targets. Inflammation and allergy},
  volume={1 3},
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors which form a subfamily of the nuclear receptor gene family. This subfamily consists of three isotypes, alpha (NR1C1), gamma (NR1C3), and beta/delta (NRC1C2) with a differential tissue distribution. PPARalpha is expressed primarily in tissues with a high level of fatty acid catabolism such as liver, brown fat, kidney, heart and skeletal muscle. PPARbeta is ubiquitously expressed, and PPARgamma has a… CONTINUE READING


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