Peroxisome proliferator activated receptors and obesity.

  title={Peroxisome proliferator activated receptors and obesity.},
  author={Sander Kersten},
  journal={European journal of pharmacology},
  volume={440 2-3},
The peroxisome proliferator activated receptors (PPARs) are a group of ligand-activated transcription factors that govern numerous biological processes, including energy metabolism, cell proliferation, and inflammation. Three different PPAR isotypes can be distinguished: alpha, beta and gamma. PPARalpha is mainly present in liver where it has an important role in the regulation of nutrient metabolism, including fatty acid oxidation, gluconeogenesis, and amino acid metabolism. It mediates the… CONTINUE READING
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