Peroxisome proliferator-activated receptors (PPARs) and their agonists for hypertension and heart failure: are the reagents beneficial or harmful?

@article{Chen2008PeroxisomePR,
  title={Peroxisome proliferator-activated receptors (PPARs) and their agonists for hypertension and heart failure: are the reagents beneficial or harmful?},
  author={Rui Chen and Fengxia Liang and Junji Moriya and Jun-ichi Yamakawa and Takashi Takahashi and Lin Shen and Tsugiyasu Kanda},
  journal={International journal of cardiology},
  year={2008},
  volume={130 2},
  pages={131-9}
}
Peroxisome proliferator-activated receptors (PPARs) alpha and gamma regulate nearly every step in cellular fatty acid uptake, utilization, oxidation, and storage pathways. They also control cell growth and migration, oxidative stress, and inflammation in the cardiovascular system. Recent studies have shown that PPARs have paradoxical effects on cardiovascular diseases, especially hypertension and heart failure. It is still unclear whether the blood pressure increases or decreases after… CONTINUE READING

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