Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction.

@article{Jackson1999PeroxisomePR,
  title={Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction.},
  author={Sue Jackson and Farhad Parhami and X P Xi and Judith A. Berliner and Willa A. Hsueh and Ronald E. Law and Linda L. Demer},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1999},
  volume={19 9},
  pages={2094-104}
}
An early event in acute and chronic inflammation and associated diseases such as atherosclerosis and rheumatoid arthritis is the induced expression of specific adhesion molecules on the surface of endothelial cells (ECs), which subsequently bind leukocytes. Peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor superfamily of transcription factors, are activated by fatty acid metabolites, peroxisome proliferators, and thiazolidinediones and are now recognized as… CONTINUE READING
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