Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway.

@article{Delerive1999PeroxisomePR,
  title={Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway.},
  author={Philippe Delerive and Françoise Martin-Nizard and Giulia Chinetti and François Trottein and Jean Charles Fruchart and Jamila Najib and Paul Duriez and Bart Staels},
  journal={Circulation research},
  year={1999},
  volume={85 5},
  pages={394-402}
}
Endothelin-1 (ET-1), a 21-amino acid vasoactive peptide mainly produced by vascular endothelial cells, is involved in the regulation of vascular tone and smooth muscle cell proliferation. Peroxisome proliferator-activated receptors (PPARs), key players in lipid and glucose metabolism, have been implicated in metabolic disorders that are predisposing to atherosclerosis. Because of the potential role of ET-1 in vascular disorders such as hypertension and atherosclerosis, we investigated the… CONTINUE READING
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