Peroxisome proliferator-activated receptor gamma overexpression inhibits pro-fibrogenic activities of immortalised rat pancreatic stellate cells.

@article{Jaster2005PeroxisomePR,
  title={Peroxisome proliferator-activated receptor gamma overexpression inhibits pro-fibrogenic activities of immortalised rat pancreatic stellate cells.},
  author={Robert Jaster and Philipp Lichte and Brit Fitzner and Peter Brock and Aenne Glass and Thomas Karopka and Lothar Gierl and Dirk Koczan and Hans-J{\"u}rgen Thiesen and Gisela Sparmann and Joerg Emmrich and Stefan Liebe},
  journal={Journal of cellular and molecular medicine},
  year={2005},
  volume={9 3},
  pages={670-82}
}
Pancreatic stellate cells (PSCs) play a key role in the development of pancreatic fibrosis, a constant feature of chronic pancreatitis and pancreatic cancer. In response to pro-fibrogenic mediators, PSCs undergo an activation process that involves proliferation, enhanced production of extracellular matrix proteins and a phenotypic transition towards myofibroblasts. Ligands of the peroxisome proliferator-activated receptor gamma (PPARgamma), such as thiazolidinediones, are potent inhibitors of… CONTINUE READING
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