Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling.

Abstract

The molecular pathogenesis of Alzheimer's disease (AD) involves the participation of the amyloid-beta-peptide (A beta), which plays a critical role in the neurodegeneration that triggers the disease. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors, which are members of the nuclear receptor family. We report… (More)

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@article{Inestrosa2005PeroxisomePR, title={Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling.}, author={Nibaldo C. Inestrosa and Juan Alejandro Godoy and Rodrigo A Quintanilla and Cecilia S. Koenig and Miguel Bronfman}, journal={Experimental cell research}, year={2005}, volume={304 1}, pages={91-104} }