Peroxisome proliferator-activated receptor gamma coactivator 1 in caloric restriction and other models of longevity.

Abstract

Dietary restriction of calories (caloric restriction [CR]) increases longevity in phylogenetically diverse species. CR retards or prevents age-dependent deterioration of tissues and an array of spontaneous and chemically induced diseases associated with obesity including cardiovascular disease, diabetes, and cancer. An understanding of the molecular… (More)

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@article{Corton2005PeroxisomePR, title={Peroxisome proliferator-activated receptor gamma coactivator 1 in caloric restriction and other models of longevity.}, author={J Christopher Corton and Holly M. Brown-Borg}, journal={The journals of gerontology. Series A, Biological sciences and medical sciences}, year={2005}, volume={60 12}, pages={1494-509} }