Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis.

@article{Lehman2000PeroxisomePR,
  title={Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis.},
  author={J. J. Lehman and P. Barger and A. Kov{\'a}cs and J. Saffitz and D. Medeiros and D. Kelly},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={106 7},
  pages={
          847-56
        }
}
Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular diseases. Recent studies have identified the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) as a regulator of mitochondrial function in tissues specialized for thermogenesis, such as brown adipose. We sought to determine whether PGC-1 controlled mitochondrial biogenesis and energy-producing capacity in the heart, a tissue specialized for high… Expand
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