Peroxisome proliferator-activated receptor gamma depletion stimulates Nox4 expression and human pulmonary artery smooth muscle cell proliferation.

@article{Bijli2015PeroxisomePR,
  title={Peroxisome proliferator-activated receptor gamma depletion stimulates Nox4 expression and human pulmonary artery smooth muscle cell proliferation.},
  author={Kaiser M. Bijli and Jennifer M. Kleinhenz and Tamara C. Murphy and Bum-Yong Kang and Sherry E. Adesina and Roy Lee Sutliff and Craig M Hart},
  journal={Free radical biology & medicine},
  year={2015},
  volume={80},
  pages={
          111-20
        }
}
Hypoxia stimulates pulmonary hypertension (PH) in part by increasing the proliferation of pulmonary vascular wall cells. Recent evidence suggests that signaling events involved in hypoxia-induced cell proliferation include sustained nuclear factor-kappaB (NF-κB) activation, increased NADPH oxidase 4 (Nox4) expression, and downregulation of peroxisome proliferator-activated receptor gamma (PPARγ) levels. To further understand the role of reduced PPARγ levels associated with PH pathobiology… CONTINUE READING