Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage.

@article{Lee2006PeroxisomePR,
  title={Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage.},
  author={C. H. Lee and Kihwa Kang and Isaac R. Mehl and Russell R. Nofsinger and William A. Alaynick and Ling-Wa Chong and John M Rosenfeld and Ronald M Evans},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 7},
  pages={
          2434-9
        }
}
Significant attention has focused on the role of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, recent advances have identified triglyceride-rich lipoproteins [e.g., very LDL (VLDL)] as independent risk predictors for this disease. We have previously demonstrated peroxisome proliferator-activated receptor (PPAR)delta, but not PPARgamma, is the major nuclear VLDL sensor in the macrophage, which is a crucial component of the atherosclerotic lesion. Here, we show… CONTINUE READING

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