Peroxisome proliferator-activated receptor delta as a molecular target to regulate lung cancer cell growth.

@article{Fukumoto2005PeroxisomePR,
  title={Peroxisome proliferator-activated receptor delta as a molecular target to regulate lung cancer cell growth.},
  author={Keiko Fukumoto and Yoshihisa Yano and Nantiga Virgona and Hiromi Hagiwara and Hiromi Sato and Hironobu Senba and Kazuyuki Suzuki and Ryuji Asano and Kazuhiko Yamada and Tomohiro Yano},
  journal={FEBS letters},
  year={2005},
  volume={579 17},
  pages={3829-36}
}
It has been assumed that prostaglandin (PG)I2 signaling contributes to the negative growth control of lung cancer cells; however, the mechanism remains unresolved. PGI2 functions through a cell surface G protein-coupled receptor (prostaglandin I2-binding receptor, IP) and also exerts an effect by interacting with a nuclear hormone receptor, peroxisome proliferator-activated receptor delta (PPARdelta). We found that PPARdelta was a key molecule of PGI2 signaling to give negative growth control… CONTINUE READING

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