Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.

@article{Schmuth2004PeroxisomePR,
  title={Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.},
  author={Matthias Schmuth and Christopher M. Haqq and William J Cairns and Julie C. Holder and Sheri Tinnell Dorsam and Sandra S Chang and Peggy Pei Zhi Lau and Ashley J Fowler and Gary S. Chuang and Arthur H. Moser and Barbara E. Brown and Man Mao-Qiang and Yoshikazu Uchida and Kristina Schoonjans and Johan Auwerx and Pierre Chambon and Timothy M Willson and Peter M Elias and Kenneth R. Feingold},
  journal={The Journal of investigative dermatology},
  year={2004},
  volume={122 4},
  pages={971-83}
}
Peroxisome proliferator-activated receptor (PPAR) are nuclear hormone receptors that are activated by endogenous lipid metabolites. Previous studies have demonstrated that PPAR-alpha activation stimulates keratinocyte differentiation in vitro and in vivo, is anti-inflammatory, and improves barrier homeostasis. Recent studies have shown that PPAR-beta/delta activation induces keratinocyte differentiation in vitro. This study demonstrated that topical treatment of mice with a selective PPAR-beta… CONTINUE READING