Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes.

@article{Ribet2010PeroxisomePR,
  title={Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes.},
  author={Carole Ribet and Emilie Montastier and Carine Valle and V{\'e}ronic B{\'e}zaire and Anne Mazzucotelli and Aline Mairal and Nathalie Viguerie and Dominique Langin},
  journal={Endocrinology},
  year={2010},
  volume={151 1},
  pages={123-33}
}
This work aimed at characterizing the role of peroxisome proliferator-activated receptors (PPAR)alpha in human white adipocyte metabolism and at comparing PPAR alpha and PPAR gamma actions in these cells. Primary cultures of human fat cells were treated with the PPAR alpha agonist GW7647 or the PPAR gamma agonist rosiglitazone. Changes in gene expression were determined using DNA microarrays and quantitative RT-PCR. Western blot and metabolic studies were performed to identify the biological… CONTINUE READING
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