Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression.

  title={Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression.},
  author={David Patsouris and Janardan K. Reddy and Michael M{\"u}ller and Sander Kersten},
  volume={147 3},
Peroxisome proliferator-activated receptors (PPARs) are transcription factors involved in the regulation of numerous metabolic processes. The PPARalpha isotype is abundant in liver and activated by fasting. However, it is not very clear what other nutritional conditions activate PPARalpha. To examine whether PPARalpha mediates the effects of chronic high-fat feeding, wild-type and PPARalpha null mice were fed a low-fat diet (LFD) or high-fat diet (HFD) for 26 wk. HFD and PPARalpha deletion… CONTINUE READING
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