Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice.

@article{Srivastava2006PeroxisomePR,
  title={Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice.},
  author={Rai Ajit K. Srivastava and Ravi Jahagirdar and Salman Azhar and Somesh Sharma and Charles L. Bisgaier},
  journal={Molecular and cellular biochemistry},
  year={2006},
  volume={285 1-2},
  pages={35-50}
}
Fenofibrate, a selective (1)PPAR-alpha activator, is prescribed to treat human dyslipidemia. The aim of this study was to delineate the mechanism of fenofibrate-mediated reductions in adiposity, improvements in insulin sensitivity, and lowering of triglycerides (TG) and free fatty acids (FFA) and to investigate if these favorable changes are related to the inhibition of lipid deposition in the aorta. To test this hypothesis we used male LDLr deficient mice that exhibit the clinical features of… CONTINUE READING

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