Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand?

@article{Peters2005PeroxisomePR,
  title={Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand?},
  author={Jeffrey M. Peters and Connie Cheung and Frank J. Gonzalez},
  journal={Journal of molecular medicine},
  year={2005},
  volume={83 10},
  pages={774-85}
}
The peroxisome proliferator-activated receptor-alpha (PPARalpha), first identified in 1990 as a member of the nuclear receptor superfamily, has a central role in the regulation of numerous target genes encoding proteins that modulate fatty acid transport and catabolism. PPARalpha is the molecular target for the widely prescribed lipid-lowering fibrate drugs and the diverse class of chemicals collectively referred to as peroxisome proliferators. The lipid-lowering function of PPARalpha occurs… CONTINUE READING

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