Peroxisome proliferator activated-receptor agonism and left ventricular remodeling in mice with chronic myocardial infarction.

@article{Frantz2004PeroxisomePA,
  title={Peroxisome proliferator activated-receptor agonism and left ventricular remodeling in mice with chronic myocardial infarction.},
  author={Stefan Frantz and Kai Hu and Julian Daniel Widder and Barbara Bayer and Catharina Clara Witzel and Isabel Schmidt and Paolo Galuppo and Joerg M. Strotmann and Georg Ertl and Johann Bauersachs},
  journal={British journal of pharmacology},
  year={2004},
  volume={141 1},
  pages={9-14}
}
1. Peroxisome proliferator activated receptor gamma (PPARgamma) has been implicated in several cellular pathways assumed to beneficially affect heart failure progression. In contrast, population-based studies demonstrate an increased incidence of heart failure in patients treated with PPARgamma agonists. Therefore, we examined the effect of pioglitazone, a PPARgamma agonist, on chronic left ventricular remodeling after experimental myocardial infarction (MI) in mice. 2. Mice were treated with… CONTINUE READING
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