Corpus ID: 4049636

Peroxisome proliferator-activated receptor alpha,gamma coagonist LY465608 inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice.

@article{Zuckerman2002PeroxisomePR,
  title={Peroxisome proliferator-activated receptor alpha,gamma coagonist LY465608 inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice.},
  author={S. Zuckerman and R. Kauffman and G. Evans},
  journal={Lipids},
  year={2002},
  volume={37 5},
  pages={
          487-94
        }
}
The apolipoprotein E (apoE) knockout mouse has provided an approach to the investigation of the effect of both cellular and humoral processes on atherosclerotic lesion progression. In the present study, pharmacologic modulation of both interferon gamma (IFNgamma)-inducible macrophage effector functions, and atherosclerotic lesions in the apoE knockout mouse were investigated using the peroxisome proliferator-activated receptor (PPAR) alpha,gamma coagonist LY465608. LY465608 inhibited, in a… Expand
Nuclear receptor mediated mechanisms of macrophage cholesterol metabolism
Underlying mechanisms of pharmacology and toxicity of a novel PPAR agonist revealed using rodent and canine hepatocytes.
  • Yin Guo, R. Jolly, +12 authors T. Ryan
  • Biology, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2007
Mouse models for atherosclerosis and pharmaceutical modifiers.
Atherosclerosis in the apolipoprotein-E-deficient mouse: a decade of progress.
...
1
2
...