Peroxisome proliferator activated receptor agonists.

@article{Kersten2000PeroxisomePA,
  title={Peroxisome proliferator activated receptor agonists.},
  author={Sander Kersten and Walter Wahli},
  journal={EXS},
  year={2000},
  volume={89},
  pages={
          141-51
        }
}
The peroxisome proliferator activated receptors (PPARs) represent a group of ligand-activated transcription factors that mediate the biological effects of various drugs, such as fibrates and thiazolidinediones. Three PPAR subtypes can be distinguished, alpha, beta and gamma, each of which has an unique pattern of expression among vertebrate tissues. The PPAR alpha receptor is activated by hypolipidemic drugs of the fibrate class, and regulates the expression of numerous genes involved in fatty… CONTINUE READING
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