Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist inhibits collagen synthesis in human hypertrophic scar fibroblasts by targeting Smad3 via miR-145.

@article{Zhu2015PeroxisomePR,
  title={Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist inhibits collagen synthesis in human hypertrophic scar fibroblasts by targeting Smad3 via miR-145.},
  author={Hua-yu Zhu and Chao Li and Zhao Zheng and Qin Zhou and Hao Guan and Lin-Lin Su and J S Han and Xiong-xiang Zhu and Shu-yue Wang and Jun Li and Dahai Hu},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={459 1},
  pages={49-53}
}
The transcription factor peroxisome proliferator-activated receptor-γ (PPAR-γ) functions to regulate cell differentiation and lipid metabolism. Recently, its agonist has been documented to regulate extracellular matrix production in human dermal fibroblasts. This study explored the underlying molecular mechanisms and gene interactions in hypertrophic scar fibroblasts (HSFBs) in vitro. HSFBs were cultured and treated with or without PPAR-γ agonist or antagonist for gene expression… CONTINUE READING
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