Peroxisome proliferator-activated receptor γ agonist pioglitazone inhibits β-catenin-mediated glioma cell growth and invasion

@article{Wan2010PeroxisomePR,
  title={Peroxisome proliferator-activated receptor γ agonist pioglitazone inhibits β-catenin-mediated glioma cell growth and invasion},
  author={Zhengqiang Wan and Wei Shi and Bai Shao and Jinlong Shi and Aiguo Shen and Yuyuan Ma and Jianchu Chen and Qing Lan},
  journal={Molecular and Cellular Biochemistry},
  year={2010},
  volume={349},
  pages={1-10}
}
Gliomas are the most common primary tumors of the central nervous system. Rapid proliferation and diffuse brain invasion of these tumors are likely to determine the unfavorable prognosis. Recent studies have shown that ligand activation of peroxisome proliferator-activated receptor γ (PPARγ) can induce differentiation and inhibit proliferation of several cancer cells. In this study, we identified pioglitazone, one PPARγ ligand in particular, suppressed human glioma cells proliferation… CONTINUE READING

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