Peroxisome proliferator-activated receptor-γ coactivator-1 and insulin resistance: acute effect of fatty acids

@article{Hoeks2006PeroxisomePR,
  title={Peroxisome proliferator-activated receptor-γ coactivator-1 and insulin resistance: acute effect of fatty acids},
  author={Joris Hoeks and Matthijs K C Hesselink and Aaron P Russell and Marco Mensink and Wim H. M. Saris and Ronald P Mensink and Patrick Schrauwen},
  journal={Diabetologia},
  year={2006},
  volume={49},
  pages={2419-2426}
}
Peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1 (PPARGC1), a coactivator regulating the transcription of genes involved in oxidative metabolism, is downregulated in patients with type 2 diabetes and in their first-degree relatives. Whether this downregulation is a cause or effect of early aberrations in the development of insulin resistance, such as disturbances in fat metabolism, is unknown. We examined whether lipid-induced insulin resistance was associated with… CONTINUE READING