Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase.

@article{Zhao2014PeroxisomePR,
  title={Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase.},
  author={Xianling Zhao and Freyr Petursson and Benoit Viollet and Martin Lotz and Robert Terkeltaub and Ru Liu-Bryan},
  journal={Arthritis & rheumatology},
  year={2014},
  volume={66 11},
  pages={
          3073-82
        }
}
OBJECTIVE AMP-activated protein kinase (AMPK) inhibits chondrocyte procatabolic responses to inflammation and biomechanical injury. This study was undertaken to test the hypothesis that peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and FoxO3A, 2 major AMPK downstream targets, mediate the chondroprotective effect of AMPK activation. METHODS We assessed the activity of AMPKα (threonine 172 phosphorylation) and the expression of PGC-1α and FoxO3A in human chondrocytes and… CONTINUE READING

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