Peroxisome proliferator-activated receptor α target genes

  title={Peroxisome proliferator-activated receptor $\alpha$ target genes},
  author={St{\'e}phane Mandard and M. M{\"u}ller and Sander Kersten},
  journal={Cellular and Molecular Life Sciences CMLS},
Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that belong to the superfamily of nuclear hormone receptors. They mediate the effects of small lipophilic compounds such as long-chain fatty acids and their derivatives on transcription of genes commonly called PPAR target genes. Here we review the involvement of PPARα in peroxisomal and mitochondrial fatty acid oxidation, microsomal fatty acid hydroxylation, lipoprotein, bile and amino acid metabolism, glucose homeostasis… 

Is hepatic peroxisome proliferator‐activated receptor α essential for the metabolic effects of fibrates?

  • Y. Kamijo
  • Biology
    Journal of gastroenterology and hepatology
  • 2018
Fibrates strongly decrease TG and increase high-density lipoprotein (HDL) cholesterol levels in the blood and are used clinically as hypolipidemic and anti-atherosclerotic medicines.

Peroxisome proliferator-activated receptor-α and liver cancer: where do we stand?

It is now established that the species difference between rodents and humans in response to peroxisome proliferators is due in part to PPAR α, and future research directions that should be taken to delineate the mechanisms underlying PPARα agonist-induced hepatocarcinogenesis are identified.

In Vivo Actions of Peroxisome Proliferator–Activated Receptors

In man, the primary effect of PPARα is to reduce plasma triglyceride concentration; effects on plasma free fatty acid (FFA) concentration/FFA oxidation, muscle/liver fat content, and muscle/hepatic insulin sensitivity have not been demonstrated with current PPARβ/δ agonists such as fenofibrate and gemfibrozil.

PPARs: Important Regulators in Metabolism and Inflammation

The ligand-activated family of peroxisome proliferator activated receptors (PPARs) consists of three members named PPARα, PPARδ and PPARγ. Each PPAR subtype is characterized by a specific tissue

The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention

There is a distinct need for a review of the literature and additional experimentation to determine the potential for targeting PPARs for cancer therapy and cancer chemoprevention.

Molecular Mechanisms of Cross-talk between Thyroid Hormone and Peroxisome Proliferator Activated Receptors: Focus on the Heart

The fundamental ways TRs and PPARs are regulated and how their cross-talk patterns mediate transcription of their target genes are reviewed.

The Role of PPARα Activation in Liver and Muscle

The involvement of PPARα in the metabolically active tissues liver and skeletal muscle is summarized and an overview of the risks and benefits of ligand activation ofPPARα is provided, with particular consideration to interspecies differences.

Peroxisome Proliferator–Activated Receptor-α: A Pivotal Regulator of the Gastrointestinal Tract

Its functions in the GIT are analyzed, including physiological control of the lipid metabolism and pathologic mediation in the progress of inflammation and the potential use of PPAR-α in treating GIT diseases and the inadequacy of clinical trials in this field.



Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids (*)

Results indicate that PPARs are differentially activated by naturally occurring eicosanoids and related molecules.

PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene.

A DNA sequence that confers a response to a class of rodent hepatocarcinogens termed peroxisome proliferators has been identified 2947bp upstream of the rat peroxISomal bifunctional enzyme gene and it is shown that two members of the steroid hormone receptor family co-operate to bind specifically to this sequence.

The peroxisome proliferator‐activated receptor α regulates amino acid metabolism

  • S. KerstenS. Mandard W. Wahli
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2001
It is concluded that in addition to oxidation of fatty acids, PPARα also regulates metabolism of amino acids in liver, indicating that PPAR α is a key controller of intermediary metabolism during fasting.

The Peroxisome Proliferator-activated Receptor α (PPARα) Regulates Bile Acid Biosynthesis*

It is shown that the induction by both treatments was dependent on the peroxisome proliferator-activated receptor α, and an effect that was abolished in the PPARα null mice, verifying the functionality of the PPRE in vivo.

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

The data demonstrate a convergence of the PPAR and RXR signaling pathways in the regulation of the peroxisomal beta-oxidation of fatty acids by fatty acids and retinoids.

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

It is shown here that specific FAs, eicosanoids, and hypolipidemic drugs are ligands for PPARα or PPARδ, and a novel conformation-based assay is developed that screens activators for their ability to bind to PPAR α/δ and induce DNA binding.