Peroxisome proliferator-activated receptor α protects capillary pericytes in the retina.

@article{Ding2014PeroxisomePR,
  title={Peroxisome proliferator-activated receptor α protects capillary pericytes in the retina.},
  author={Lexi Ding and Rui Cheng and Yang Hu and Yusuke Takahashi and Alicia Josephine Jenkins and Anthony C Keech and Kenneth M Humphries and Xiaowu Gu and Michael H. Elliott and Xiaobo Xia and Jian-xing Ma},
  journal={The American journal of pathology},
  year={2014},
  volume={184 10},
  pages={2709-20}
}
Pericyte degeneration is an early event in diabetic retinopathy and plays an important role in progression of diabetic retinopathy. Clinical studies have shown that fenofibrate, a peroxisome proliferator-activated receptor α (PPARα) agonist, has robust therapeutic effects on diabetic retinopathy in type 2 diabetic patients. We evaluated the protective effect of PPARα against pericyte loss in diabetic retinopathy. In streptozotocin-induced diabetic mice, fenofibrate treatment significantly… CONTINUE READING