Peroxisome proliferator-activated receptor α,γ coagonist LY465608 inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice

@article{Zuckerman2002PeroxisomePR,
  title={Peroxisome proliferator-activated receptor $\alpha$,$\gamma$ coagonist LY465608 inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice},
  author={S. Zuckerman and R. Kauffman and G. Evans},
  journal={Lipids},
  year={2002},
  volume={37},
  pages={487-494}
}
The apolipoprotein F (apoF) knockout mouse has provided an approach to the investigation of the effect of both cellular and humoral processes on atherosclerotic lesion progression. In the present study, pharmacologic modulation of both interferon gamma (IFNγ)-inducible macrophage effector functions, and atherosclerotic lesions in the apoE knockout mouse were investigated using the peroxisome proliferator-activated receptor (PPAR) α,γ coagonist LY465608. LY465608 inhibited, in a concentration… Expand

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