Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle.

@article{Cha2001PeroxisomePR,
  title={Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle.},
  author={Bong Soo Cha and Theodore P. Ciaraldi and L Carter and Svetlana E Nikoulina and Sangeeta Mudaliar and Reena Mukherjee and James R. Paterniti and Robert R. Henry},
  journal={Diabetologia},
  year={2001},
  volume={44 4},
  pages={444-52}
}
AIMS/HYPOTHESIS To determine the independent and potentially synergistic effects of agonists for PPAR gamma and RXR on glucose and lipid metabolism, as well as gene expression, in human skeletal muscle cell cultures. METHODS Fully differentiated myotubes from non-diabetic subjects and subjects with Type II (non-insulin-dependent) diabetes mellitus were chronically (2 days) treated with LG100268 (4 mumol/l), an RXR agonist, or troglitazone (4.6 mumol/l), a PPAR gamma agonist or both, to… CONTINUE READING

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