Peroxisome proliferation in primary cultures of rat hepatocytes.

  title={Peroxisome proliferation in primary cultures of rat hepatocytes.},
  author={Tim J. B. Gray and Brian G Lake and Jenny A. Beamand and John R. Foster and S. D. Gangolli},
  journal={Toxicology and applied pharmacology},
  volume={67 1},
Primary cultures of rat hepatocytes were exposed to a range of chemicals known to cause peroxisome proliferation in vivo. Peroxisomal palmitoyl-CoA oxidation and carnitine acetyltransferase (CAT) activity were increased within 12 to 24 hr of adding 0.5 mM clofibrate to the culture medium, reaching about 20 times control levels after 72 hr. Stimulation of CAT activity was dose related over a concentration range of 0.05 to 2 mM clofibrate and 0.02 to 0.2 mM mono-2-ethylhexylphthalate (MEHP… CONTINUE READING


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