Peroxisome Proliferator-Activated Receptor d ( PPAR d ) Induces Estrogen Receptor-Positive Mammary Neoplasia through an In fl ammatory andMetabolic Phenotype Linked to mTor Activation

@inproceedings{Yuan2013PeroxisomePR,
  title={Peroxisome Proliferator-Activated Receptor d ( PPAR d ) Induces Estrogen Receptor-Positive Mammary Neoplasia through an In fl ammatory andMetabolic Phenotype Linked to mTor Activation},
  author={Hongyan Yuan and Jin Lu and Junfeng Xiao and Geeta Upadhyay and Rachel L. Umans and Bhaskar Kallakury and Yuhzi Yin and Michael E. Fant and Levy Kopelovich and Robert I Glazer},
  year={2013}
}
The peroxisome proliferator-activated receptor-d (PPARd) regulates a multitude of physiological processes associated with glucose and lipid metabolism, inflammation, and proliferation. One or more of these processes are potential risk factors for the ability of PPARd agonists to promote tumorigenesis in themammary gland. In this study, we describe a new transgenic mouse model in which activation of PPARd in the mammary epithelium by endogenous or synthetic ligands resulted in progressive… CONTINUE READING