Peroxisome Proliferator-Activated Receptor Protects Against Alcohol-Induced Liver Damage

@inproceedings{Nakajima2004PeroxisomePR,
  title={Peroxisome Proliferator-Activated Receptor Protects Against Alcohol-Induced Liver Damage},
  author={Tamie Nakajima and Yuji Kamijo and Naoki Tanaka and Eiko Sugiyama and Eiji Tanaka and Kendo Kiyosawa and Yoshimitsu Fukushima and Jeffrey M. Peters and Frank J. Gonzalez and Toshifumi Aoyama},
  year={2004}
}
The mechanisms underlying alcoholic liver disease are not completely understood, but lipid accumulation seems to be central to the cause of this disease. The peroxisome proliferatoractivated receptor (PPAR ) plays an important role in the control of lipid homeostasis, metabolism of bioactive molecules, and modulation of inflammatory responses. To investigate the roles of PPAR in alcoholic liver injury, wild-type and PPAR -null mice were continuously fed a diet containing 4% ethanol, and liver… CONTINUE READING

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