Peroxisome Proliferator-Activated Receptor Gene Variants Influence Progression of Coronary Atherosclerosis and Risk of Coronary Artery Disease

@inproceedings{Flavell2002PeroxisomePR,
  title={Peroxisome Proliferator-Activated Receptor Gene Variants Influence Progression of Coronary Atherosclerosis and Risk of Coronary Artery Disease},
  author={David M. Flavell and Yalda Jamshidi and Emma Hawe and In{\'e}s Pineda Torra and Marja-Riitta Taskinen and Maria Frick and Markku S Nieminen and Yrj{\"o} Antero Kes{\"a}niemi and Amos Pasternack and Bart Staels and George J. Miller and Steve E Humphries and Philippa J. Talmud and Mikko Syv{\"a}nne},
  year={2002}
}
Background—Peroxisome proliferator-activated receptor (PPAR ) regulates the expression of genes involved in lipid metabolism and inflammation, making it a candidate gene for atherosclerosis and ischemic heart disease (IHD). Methods and Results—We investigated the association between the leucine 162 to valine (L162V) polymorphism and a G to C transversion in intron 7 of the PPAR gene and progression of atherosclerosis in the Lopid Coronary Angiography Trial (LOCAT), a trial examining the effect… CONTINUE READING

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Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1

  • P Delerive, K De Bosscher, S Besnard
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