Peroxisome Proliferator-Activated Receptor (PPAR)-α: A Pharmacological Target with a Promising Future

@article{Raalte2004PeroxisomePR,
  title={Peroxisome Proliferator-Activated Receptor (PPAR)-α: A Pharmacological Target with a Promising Future},
  author={D. V. van Raalte and M. Li and P. Pritchard and K. Wasan},
  journal={Pharmaceutical Research},
  year={2004},
  volume={21},
  pages={1531-1538}
}
Peroxisome proliferator-activated receptor (PPAR)-α is a ligand-activated transcriptional factor that belongs to the family of nuclear receptors. PPAR-α regulates the expression of genes involved in fatty acid β-oxidation and is a major regulator of energy homeostasis. Fibrates are PPAR-α agonists and have been used to treat dyslipidemia for several decades because of their triglyceride (TG) lowering and high- density lipoprotein cholesterol (HDL-C) elevating effects. More recent research has… Expand
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