Peroxisome Proliferator-Activated Receptor γ is a Sensitive Target for Oil Sands Process-Affected Water: Effects on Adipogenesis and Identification of Ligands.

@article{Peng2016PeroxisomePR,
  title={Peroxisome Proliferator-Activated Receptor γ is a Sensitive Target for Oil Sands Process-Affected Water: Effects on Adipogenesis and Identification of Ligands.},
  author={Hui Peng and Jianxian Sun and Hattan A. Alharbi and Paul D. A. Jones and John Paul Giesy and Steve B. Wiseman},
  journal={Environmental science & technology},
  year={2016},
  volume={50 14},
  pages={7816-24}
}
Identification of toxic components of complex mixtures is a challenge. Here, oil sands process-affected water (OSPW) was used as a case study to identify those toxic components with a known protein target. Organic chemicals in OSPW exhibited dose-dependent activation of peroxisome proliferator-activated receptor γ (PPARγ) at concentrations less than those currently in the environment (0.025× equivalent of full-strength OSPW), by use of a luciferase reporter gene assay. Activation of PPAR… CONTINUE READING
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