Peroxisome Proliferator-Activated Receptor γ Negatively Regulates Allergic Rhinitis in Mice.

@article{Fukui2009PeroxisomePR,
  title={Peroxisome Proliferator-Activated Receptor γ Negatively Regulates Allergic Rhinitis in Mice.},
  author={Naoko Fukui and Kohei Honda and Eiko Ito and Kazuo Ishikawa},
  journal={Allergology international : official journal of the Japanese Society of Allergology},
  year={2009},
  volume={58 2},
  pages={247-253}
}
BACKGROUND Peroxisome proliferator-activated receptor γ (PPAR-γ) has been shown to play an important role in the control of inflammatory responses acting on macrophages, mast cells, T cells, and eosinophils. The present study was aimed at investigating the effects of PPAR-γ agonist on nasal symptoms and eosinophil accumulations in nasal mucosa by using a murine allergic rhinitis model. Furthermore, we examined the expression of PPAR-γ in the nasal mucosa in mice. METHODS BALB/c mice were… CONTINUE READING

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