Peroxisome Proliferator-Activated Receptor γ Ligands Retard Cultured Vascular Smooth Muscle Cells Calcification Induced by High Glucose

@article{Zhou2012PeroxisomePR,
  title={Peroxisome Proliferator-Activated Receptor γ Ligands Retard Cultured Vascular Smooth Muscle Cells Calcification Induced by High Glucose},
  author={Ye-Bo Zhou and Jing Zhang and Ding-Qiong Peng and Jin-rui Chang and Yan Wei Cai and Y Yu and Mo-Zhi Jia and Wei Wu and You-fei Guan and Chao-shu Tang and Yong-fen Qi},
  journal={Cell Biochemistry and Biophysics},
  year={2012},
  volume={66},
  pages={421-429}
}
Peroxisome proliferator-activated receptor γ (PPARγ) and its ligands have profound effects on glucose homeostasis, cardiovascular diseases, and bone metabolism. To explore the pathophysiological roles of PPARγ in diabetes with concomitant vascular calcification, we investigated changes in PPARγ expression and the effect of the PPARγ ligands troglitazone and rosiglitazone on vascular smooth muscle cell (VSMC) calcification induced by high glucose (HG, 25 mmol/L). Compared with low glucose, HG… CONTINUE READING