Peroxisome Proliferator-Activated Receptor γ Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction.

Abstract

Peroxisome proliferator-activated receptor (PPAR) γ is critical for alveolar macrophage (AM) function. Chronic alcohol abuse causes AM phagocytic dysfunction and susceptibility to respiratory infections by stimulating nicotinamide adenine dinucleotide oxidases (Nox), transforming growth factor-β1, and oxidative stress in the AM. Because PPARγ inhibits Nox… (More)
DOI: 10.1165/rcmb.2015-0077OC

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@article{Yeligar2016PeroxisomePR, title={Peroxisome Proliferator-Activated Receptor γ Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction.}, author={Samantha M. Yeligar and Ashish Jitendra Mehta and Frank L. Harris and Lou Ann Scism Brown and C. Michael M. Hart}, journal={American journal of respiratory cell and molecular biology}, year={2016}, volume={55 1}, pages={35-46} }