Peroxisomal fatty acid oxidation is selectively inhibited by phenothiazines in isolated hepatocytes.

@article{Leighton1984PeroxisomalFA,
  title={Peroxisomal fatty acid oxidation is selectively inhibited by phenothiazines in isolated hepatocytes.},
  author={Federico M Leighton and R P{\'e}rsico and Cecilia Necochea},
  journal={Biochemical and biophysical research communications},
  year={1984},
  volume={120 2},
  pages={505-11}
}
The production of hydrogen peroxide by isolated hepatocytes in response to lauric, palmitic and oleic acids, a measurement of peroxisomal fatty acid oxidation, is inhibited by phenothiazines under conditions in which ketone body production, a measurement of mitochondrial fatty acid oxidation, does not reveal inhibition of mitochondrial activity. This novel finding provides a pharmacological tool for the study of peroxisomal function in whole cells. The mechanism of this effect of phenothiazines… CONTINUE READING

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