Peroxisomal β-oxidation — A metabolic pathway with multiple functions

  title={Peroxisomal β-oxidation — A metabolic pathway with multiple functions},
  author={Yves Poirier and Vasily D. Antonenkov and Tuomo Glumoff and J Kalervo Hiltunen},
Fatty acid degradation in most organisms occurs primarily via the β-oxidation cycle. In mammals, β-oxidation occurs in both mitochondria and peroxisomes, whereas plants and most fungi harbor the β-oxidation cycle only in the peroxisomes. Although several of the enzymes participating in this pathway in both organelles are similar, some distinct physiological roles have been uncovered. Recent advances in the structural elucidation of numerous mammalian and yeast enzymes involved in β-oxidation… CONTINUE READING