Peroxiredoxin gene expression signatures in liver reflect toxic insult.

  title={Peroxiredoxin gene expression signatures in liver reflect toxic insult.},
  author={Rachel Young and John D. Hayes and Ken Brown and C. R. Wolf and Christopher Bruce Alexander Whitelaw},
  journal={Assay and drug development technologies},
  volume={8 4},
The oxidative stress response is an important pathway involved in maintaining redox homeostasis in cells, preventing damage induced by free radicals and reactive oxygen species. The central regulator of this response is the transcription factor Nrf2. Nrf2 modulates expression of the oxidative stress genes via the antioxidant response element (ARE). Oxidative stress in cells may be both a cause of toxicity and a result of adaptation or cell death. To investigate whether the oxidative stress… CONTINUE READING


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