Peroxiredoxin II is an antioxidant enzyme that negatively regulates collagen-stimulated platelet function.

@article{Jang2015PeroxiredoxinII,
  title={Peroxiredoxin II is an antioxidant enzyme that negatively regulates collagen-stimulated platelet function.},
  author={Ji Yong Jang and Su Bin Wang and Ji Hyun Min and Yun Hee Chae and Jin Young Baek and D I Yu and Tong-Shin Chang},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 18},
  pages={11432-42}
}
Collagen-induced platelet signaling is mediated by binding to the primary receptor glycoprotein VI (GPVI). Reactive oxygen species produced in response to collagen have been found to be responsible for the propagation of GPVI signaling pathways in platelets. Therefore, it has been suggested that antioxidant enzymes could down-regulate GPVI-stimulated platelet activation. Although the antioxidant enzyme peroxiredoxin II (PrxII) has emerged as having a role in negatively regulating signaling… CONTINUE READING
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GPVI and integrin alphaIIb beta3 signaling in platelets.

Journal of thrombosis and haemostasis : JTH • 2005
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