Peroxiredoxin 6 as an antioxidant enzyme: protection of lung alveolar epithelial type II cells from H2O2-induced oxidative stress.

Abstract

We evaluated the antioxidant role of peroxiredoxin 6 (Prdx6) in primary lung alveolar epithelial type II cells (AEC II) that were isolated from wild type (WT), Prdx6-/-, or Prdx6 transgenic (Tg) overexpressing mice and exposed to H(2)O(2) at 50-500 microM for 1-24 h. Expression of Prdx6 in Tg AEC II was sevenfold greater than WT. Prdx6 null AEC II exposed… (More)
DOI: 10.1002/jcb.21703

Topics

5 Figures and Tables

Cite this paper

@article{Wang2008Peroxiredoxin6A, title={Peroxiredoxin 6 as an antioxidant enzyme: protection of lung alveolar epithelial type II cells from H2O2-induced oxidative stress.}, author={Yan Wang and Sheldon I. Feinstein and Aron B. Fisher}, journal={Journal of cellular biochemistry}, year={2008}, volume={104 4}, pages={1274-85} }