Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice.

@article{Park2011Peroxiredoxin2D,
  title={Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice.},
  author={Jong-Gil Park and Ji-Young Yoo and Se-Jin Jeong and Jae-Hoon Choi and Mi-Ran Lee and Mi-Ni Lee and Jeong Hwa Lee and Hyoung Chin Kim and Hanjoong Jo and dAE-yEUL yU and Sang Won Kang and Sue Goo Rhee and Mun-Han Lee and Goo Taeg Oh},
  journal={Circulation research},
  year={2011},
  volume={109 7},
  pages={
          739-49
        }
}
RATIONALE Peroxiredoxin 2 (Prdx2), a thiol-specific peroxidase, has been reported to regulate proinflammatory responses, vascular remodeling, and global oxidative stress. OBJECTIVE Although Prdx2 has been proposed to retard atherosclerosis development, no direct evidence and mechanisms have been reported. METHODS AND RESULTS We show that Prdx2 is highly expressed in endothelial and immune cells in atherosclerotic lesions and blocked the increase of endogenous H(2)O(2) by atherogenic… CONTINUE READING

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Cell Stress Proteins in Atherothrombosis

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  • 2012
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