Peroxiredoxin 1 inhibits the oxidative stress induced apoptosis in renal tubulointerstitial fibrosis.

@article{Mei2015Peroxiredoxin1I,
  title={Peroxiredoxin 1 inhibits the oxidative stress induced apoptosis in renal tubulointerstitial fibrosis.},
  author={Wenjuan Mei and Zhangzhe Peng and Miaomiao Lu and Chun-yan Liu and Zhenghao Deng and Yun Xiao and Jishi Liu and Ying He and Qiongjing Yuan and Xiangning Yuan and Damu Tang and Huixiang Yang and Lijian Tao},
  journal={Nephrology},
  year={2015},
  volume={20 11},
  pages={832-42}
}
AIM Apoptosis is one of the most important mechanisms underlying renal tubulointerstitial fibrosis. We identified a role of protein Peroxiredoxin 1 (Prx1) in protecting apoptosis occurred in tubular epithelial cells of the rat and human kidney. METHODS Immunohistochemistry (IHC) staining was used to detect Prx1 expression in kidney derived from unilateral-ureteral obstruction (UUO) rats or patients with obstructive nephropathy. Modulation of Prx1 expression by transfecting siRNA and… CONTINUE READING