Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells.

@article{Jarvis2012Peroxiredoxin1F,
  title={Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells.},
  author={Reagan M Jarvis and Stephanie M Hughes and Elizabeth C Ledgerwood},
  journal={Free radical biology & medicine},
  year={2012},
  volume={53 7},
  pages={1522-30}
}
Hydrogen peroxide is widely viewed as the main second messenger in redox signaling, and it has been proposed that deactivation of the antioxidant peroxiredoxin (Prdx) enzymes allows free peroxide to accumulate and directly oxidize target proteins (the floodgate model). We assessed the role of cytosolic Prdxs 1 and 2 in peroxide-induced activation of the apoptosis signaling kinase 1 (ASK1)/p38 signaling pathway, in which oxidation of ASK1 is required for phosphorylation of p38. In response to… CONTINUE READING

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