Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase.

@article{Aeby2016Peroxiredoxin1P,
  title={Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase.},
  author={Eric Aeby and Wareed Ahmed and Sophie Redon and Viesturs Simanis and Joachim Lingner},
  journal={Cell reports},
  year={2016},
  volume={17 12},
  pages={
          3107-3114
        }
}
  • Eric Aeby, Wareed Ahmed, +2 authors Joachim Lingner
  • Published in Cell reports 2016
  • Biology, Medicine
  • Oxidative damage of telomeres can promote cancer, cardiac failure, and muscular dystrophy. Specific mechanisms protecting telomeres from oxidative damage have not been described. We analyzed telomeric chromatin composition during the cell cycle and show that the antioxidant enzyme peroxiredoxin 1 (PRDX1) is enriched at telomeres during S phase. Deletion of the PRDX1 gene leads to damage of telomeric DNA upon oxidative stress, revealing a protective function of PRDX1 against oxidative damage at… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 22 CITATIONS

    Catalytic and Signaling Role of Peroxiredoxins in Carcinogenesis

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Oxidative Stress: Role and Response of Short Guanine Tracts at Genomic Locations

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Peroxiredoxins in Cancer and Response to Radiation Therapies

    VIEW 3 EXCERPTS
    CITES BACKGROUND