Peroxiredoxin: a central player in immune modulation.

  title={Peroxiredoxin: a central player in immune modulation.},
  author={M W Robinson and Andrew T Hutchinson and John Pius Dalton and Sheila Donnelly},
  journal={Parasite immunology},
  volume={32 5},
Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS released by host immune effector cells. However, we recently reported that helminth-secreted Prx also contribute to the development of Th2-responses via a mechanism involving the induction of alternatively activated macrophages. In this review, we… CONTINUE READING

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