Peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3-II.

@article{Jiang2015PeroxinPI,
  title={Peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3-II.},
  author={Li Jiang and Sayuri Hara-Kuge and Shun-ichi Yamashita and Yukio Fujiki},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2015},
  volume={20 1},
  pages={
          36-49
        }
}
Pexophagy can be experimentally induced in mammalian cells by removing the culture serum. Pex14p, a peroxisomal membrane protein essential for matrix protein import in docking of soluble receptor Pex5p, is involved in the mammalian autophagic degradation of peroxisomes and interacts with the lipidated form of LC3, termed LC3-II, an essential factor for autophagosome formation, under the starvation condition in CHO-K1 cells. However, molecular mechanisms underlying the Pex14p-LC3-II interaction… CONTINUE READING
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